Discover why KSM-66® Ashwagandha is one of the most clinically researched extracts for supporting the body’s stress response. This premium ingredient is also shown to assist with cognitive function, physical performance, sleep quality, and hormonal levels.
At Bioglan, we prioritise evidence-based ingredients like KSM-66®, combining herbal knowledge with modern clinical science to deliver reliable, high-quality formulations.
KSM-66® Ashwagandha is a high-concentration, full-spectrum root extract derived from Withania somnifera, a plant used traditionally in Ayurvedic medicine to support vitality, resilience, and overall wellbeing.
Produced by Ixoreal Biomed, KSM-66® uses a unique water-based extraction process that preserves the natural balance of active compounds, particularly withanolides, without the use of alcohol or chemical solvents.
This approach ensures consistency, purity, and a profile.
KSM-66® supports the body through multiple biological systems involved in stress, mood, and recovery.
KSM-66® mode of action is proposed to regulate the hypothalamic-pituitary-adrenal (HPA) axis, the system responsible for controlling the body’s stress response. By supporting this pathway, it assists in maintaining healthy cortisol levels.
KSM-66® is thought to influence key brain chemicals involved in mood and cognition, including:
It also supports the body’s natural defence systems by helping reduce oxidative stress and inflammation, which can impact recovery and overall wellbeing.
Not all ashwagandha extracts are the same. Differences in plant part, extraction method, and clinical research can influence how each extract performs in the body.
| Ashwagandha Type | Plant Part Used | Withanolide Content | Extraction Method | Focus | Clinical Evidence |
|---|---|---|---|---|---|
| KSM-66® | Root only | ≥5% | Water-based | Balance of actives, holistic extract | 34+ RCTs |
| Sensoril® | Root + Leaf | 10% | Alcohol-based | Higher potency, shorter-term stress focus | 10+ RCTs |
| Shoden® | Root + Leaf | 35% (glycowithanolides) |
Solvent-based | Fast-acting energy and cognition | 6+ RCTs |
KSM-66® offers a root-only composition aligned with Ayurvedic tradition and backed by the largest clinical research portfolio of any ashwagandha extract.
References:
Ixoreal Biomed. KSM-66® Ashwagandha Technical Dossier
Natreon Inc. Sensoril® Ashwagandha Product Monograph
Arjuna Natural. Shoden® Ashwagandha Clinical & Technical Data
Chandrasekhar et al., 2012. Indian J Psychol Med
Wankhede et al., 2015. J Int Soc Sports Nutr
KSM-66® helps the body adapt to physical and emotional stress, helping support emotional wellbeing and relieves symptoms of mild anxiety.
By supporting neurotransmitter activity, it assists with brain function, memory, mental recall and maintaining a healthy balanced mood during periods of stress.
In active individuals and male athletes, KSM-66® supports:
Used as an aphrodisiac, KSM-66® supports:
By supporting a healthy stress response in the body and supporting the nervous system function, KSM-66® helps reduce sleeplessness and improve overall sleep quality, supporting recovery and daily performance.
Explore our full range of Ashwagandha supplements
KSM-66® has been evaluated for safety and tolerability in multiple studies, with no significant adverse effects reported when used as directed.
At Bioglan, ingredient selection is driven by scientific evidence, quality, and consistency.
KSM-66® is chosen because it:
This aligns with our commitment to developing targeted, evidence-based formulations that consumers and healthcare professionals can trust.
KSM-66® Ashwagandha is a clinically validated, full-spectrum root extract that supports the body’s ability to manage stress while also benefiting cognitive function, physical performance, sleep, and hormonal health.
By combining herbal knowledge with modern scientific validation, it offers a comprehensive and natural approach to supporting overall wellbeing.
